Because of comparable pharmacologic properties, it really is affordable to count on comparable hazard with concomitant use of opioid cough remedies and benzodiazepines, other CNS depressants, or Liquor.

Anticholinergics – Concomitant use of other brokers with anticholinergic Homes must be undertaken with warning.

Promethazine hydrochloride takes place as a white to faint yellow, nearly odorless, crystalline powder which slowly but surely oxidizes and turns blue on prolonged publicity to air.

The narcotic antagonist, naloxone hydrochloride, can be administered when significant respiratory despair occurs with promethazine and codeine; any depressant results of promethazine will not be reversed with naloxone. Diazepam could be made use of to control convulsions. Stay away from analeptics, which can bring about convulsions. Acidosis and electrolyte losses ought to be corrected. An increase in temperature or pulmonary complications may well signal the necessity for establishment of antibiotic therapy.

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A heightened risk of unique malformations with codeine publicity such as respiratory malformations, spina bifida and congenital heart defects had been claimed in certain research.

This medication may perhaps make you much more delicate for the Solar. Restrict your time in the Sunshine. Stay away from tanning booths and sunlamps. Use sunscreen and put on protective clothes when outdoors. Tell your medical professional without delay if you get sunburned or have pores and skin blisters/redness.

Stimulation might be apparent, particularly in young children and geriatric patients. Convulsions may well not often come about. A paradoxical reaction has long been described in little ones receiving single doses of 75 mg to a hundred twenty five mg orally, characterized by hyperexcitability and nightmares.

The bottom effective dosage need to be applied, and also other medicines that affect respiration needs to be avoided. Get clinical help immediately in the not likely occasion that sluggish/shallow respiratory occurs. Promethazine really Promethazine codeine syrup should not be employed by kids with liver disease (like feasible Reyes syndrome).

Promethazine has an elimination half-life of ten-fourteen hrs, with excretion of metabolites appearing within the urine and feces. The sulfoxides of promethazine and N-demethylpromethazine would be the predominant metabolites appearing in the urine.

In advance of using this medication, tell your medical professional or pharmacist if you are allergic to any of its substances; or to opioid pain relievers (including morphine); or For those who have every other allergy symptoms.

To lessen the chance of dizziness and lightheadedness, stand up slowly when growing from a sitting down or lying position.

Codeine is understood being substantially excreted because of the kidney, and the chance of adverse reactions to this drug might be increased in clients with impaired renal perform.

The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric people lower than 6 decades of age, mainly because The mixture might trigger fatal respiratory depression On this age population. It's important that promethazine with codeine syrup is calculated having an exact measuring device (see Safety measures-Info For Patients).